Antibiotics For Low Back Pain?
- At March 31, 2025
- By Healing In Motion
- In Research
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Persica Pharmaceuticals has developed PP353, an intradiscal injection designed to treat chronic low back pain linked to bacterial infections, particularly cases associated with Modic changes (pathological alterations in vertebrae seen on MRI). PP353 combines:
- Linezolid (antibiotic) – targets bacterial infection
- Iohexol (contrast agent) – aids imaging and distribution
- Thermosensitive gel – ensures controlled release
Recent Study & Findings
- Conducted on 44 patients
- Patients received two injections four days apart
- 60% reported significant pain and disability reduction
- Study supports infectious origins in some chronic back pain cases
Potential Impact
- Could benefit the 25% of chronic low back pain cases linked to bacterial infection
- Offers a minimally invasive alternative to surgery or long-term medication
- Further clinical trials required before widespread use
